Effect of Vitamin E and Metformin on Fatty Liver Disease in Obese Children- Randomized Clinical Trial

نویسندگان

  • Kobra SHIASI ARANI
  • Abbas TAGHAVI ARDAKANI
  • Razieh MOAZAMI GOUDARZI
  • Hamid reza TALARI
  • Kamran HAMI
  • Hossein AKBARI
  • Nima AKBARI
چکیده

BACKGROUND We evaluated the effect of vitamin E and metformin on fatty liver disease in obese children. METHODS This interventional study has been done on 119 children with Non-alcoholic fatty liver disease (based on sonography results). Patients were divided into four treatment groups; they received metformin 1gr daily (age< 12 years), metformin 1.5 gr daily (age> 12 years), vitamin E 800 U daily and vitamin E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials (IRCT), No.IRCT2013021012421N1. RESULTS The study group comprised 119 individuals (62 females, 57 males). The mean age was 10± 3.19 yr. There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients (55.46%), 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received vitamin E 800 u daily (48.1%) and the least therapeutic response was in the group which received vitamin E 400 u daily (14.3%). After four months, the greater response was seen in vitamin E 400 u daily group (45.8%) and the least response in the metformin 1 gram daily group (19%). CONCLUSION In comparison with metformin, vitamin E is more influential in remission; however both are efficient in treatment of fatty liver. Vitamin E 400 u daily responses better in four-month treatment.

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عنوان ژورنال:

دوره 43  شماره 

صفحات  -

تاریخ انتشار 2014